This collection is made up of works for children. It is comprised of bibliographies, specialised reference works, library catalogues, monographs, and Spanish and foreign children's literature study guides. There are also comic books, story books, picture books, illustrated books, fiction, poetry, theatre and educational texts.
The collection originated by Ministerial Order in 1971 (M.O. 18 December), which created a section in the Biblioteca Nacional called the "Isabel Niño Library for the Study of Children's and Young Adult Literature". The section was eliminated from main base organisational structure of the Biblioteca Nacional by M.O. in 1986, and its assets were included in the depositories of the Biblioteca Nacional.